What is a likely effect of platelet-derived growth factor (PDGF) action on cells with PDGF receptors?

The action of platelet-derived growth factor (PDGF) on cells with PDGF receptors primarily leads to cell proliferation, especially in the context of wound healing. PDGF is a potent mitogen, meaning it encourages cells to divide and proliferate. After an injury, PDGF is released by platelets and other cells, initiating a cascade of events that promotes the movement and multiplication of various cell types, including fibroblasts and smooth muscle cells, in the area of the wound.

This response is critical for tissue regeneration as the increased number of cells helps in rebuilding the extracellular matrix, promoting tissue repair, and facilitating the overall healing process. Thus, when PDGF binds to its receptors on target cells, it activates signaling pathways that drive these cells to progress through the cell cycle, leading to enhanced proliferation at the wound site.

The other options do not align with the primary biological function of PDGF. For instance, PDGF does not trigger necrosis as that refers to unregulated cell death, nor does it tone down the expression of genes related to cell cycle regulation, as it primarily promotes these processes. Instead, its main role in the context of cellular activities is to stimulate growth and division, making option C the most accurate reflection of PDGF action